Synthesis, Characterization and Biological Properties of Type I Collagen–Chitosan Mixed Hydrogels: A Review

Type I collagen and chitosan are two of the main biological macromolecules used to design scaffolds for tissue engineering. The former has benefits being biocompatible provides biochemical cues cell adhesion, proliferation differentiation. However, hydrogels usually exhibit poor mechanical properties difficult functionalize. Chitosan is also often biocompatible, but much more versatile in terms structure chemistry. Although it does have important properties, not a good substrate mammalian cells. Combining these biomacromolecules therefore strategy choice preparation interesting biomaterials. aim this review describe different protocols available prepare collagen–chitosan purpose presenting their physical chemical highlighting mixed over single-macromolecule ones. A critical discussion literature provided point out understanding chitosan–type interactions, particular due lack systematic studies addressing effect characteristics.